12. Deryabina O. N., Plotnikova N. A., Radynova S. B. Dynamics of morphogenesis under the influence of melatonin and mexidol in conditions of induced carcinogenesis

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UDC 615.03:612.014.3

DOI: 10.15507/0236-2910.027.201703.452-464

Dynamics of morphogenesis under the influence of melatonin and mexidol in the context of induced carcinogenesis

Olga N. Deryabina
Associated Professor of Chair of Oncology with Course of Radiation Diagnostics and Radiation Therapy, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Ph.D. (Medicine), Docent, ORCID: http://orcid.org/0000-0002-8814-3369, This email address is being protected from spambots. You need JavaScript enabled to view it.

Nadezhda A. Plotnikova
Head of Chair of Normal and Pathological Anatomy with Course of Forensic Medicine, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Dr.Sci. (Medicine), Professor, This email address is being protected from spambots. You need JavaScript enabled to view it.

Svetlana B. Radynova
Associated Professor of Chair of Obstetrics and Gynecology, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Ph.D.(Medicine), Docent, This email address is being protected from spambots. You need JavaScript enabled to view it.

Introduction: The article deals with the effect of mexidol and melatonin in the separate and combined use, on the process of carcinogenesis of soft tissue induced by benzopyrene at mice.
Materials and Methods: 120 mice were divided into four groups: three experimental groups of 30 mice, 30 mices are the control group on carcinogen. Animals from the all four groups were applied with benzoapyrene at a dose of 0.2 ml per mouse, 2 times a week.
Results: It is found that the histological examination has showed a pattern similar to malignant fibrous histiocytoma. In the application of melatonin, the number of animals with induced tumors was 57 %, under the influence of mexidol frequency of formation of tumor nodes was 50 %. With combined use of mexidol and melatonin, the number of mice which had progressing tumor nodes was 36.6 %.
Discussion and Conclusions: While induced tumor growth of soft tissue, we can identify the various stages of the morphogenesis of malignancy.

Keywords: induced carcinogenesis, mesenchymal tumors, morphogenesis, melatonin, mexidol

For citation: Deryabina O. N., Plotnikova N. A., Radynova S. B. Dynamics of morphogenesis under the influence of melatonin and mexidol in conditions of induced carcinogenesis. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2017; 27(3):452–464. DOI: 10.15507/0236-2910.027.201703.452-464

Contribution of the co-authors: N. A. Plotnikova: scientific guidance, analysis and revision of the final text; O. N. Deryabina: writing the draft, analysis of literature data; S. B. Radynova: rewiewing the relevant literature, word processing.

This work is licensed under a Creative Commons Attribution 4.0 License.