04. Shamonina T. N., Radaeva O. A., Novikova L. V. The role of T-511C polymorphism in the IL-1β gene in patients with arterial hypertension and metabolic syndrome and its association with the risk of developing chronic heart failure

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UDC 612.014.24:616.1

DOI: 10.15507/0236-2910.027.201703.345-354

The role of T-511C polymorphism in the IL-1β gene in patients with arterial hypertension and metabolic syndrome and its association with the risk of developing chronic heart failure

Tatyana N. Shamonina
Assistant of Chair of Immunology, Microbiology and Virology, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), ORCID: http://orcid.org/0000-0003-0225-3602, This email address is being protected from spambots. You need JavaScript enabled to view it.

Olga А. Radaeva
Associate Professor of Chair of Immunology, Microbiology and Virology, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Ph.D. (Medicine), ORCID: http://orcid.org/0000-0003-1383-2474, This email address is being protected from spambots. You need JavaScript enabled to view it.

Lyudmila V. Novikova
Head of Chair of Immunology, Microbiology and Virology, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Ph.D. (Medicine), Professor, ORCID: http://orcid.org/0000-0001-8279-7495, This email address is being protected from spambots. You need JavaScript enabled to view it.

Introduction: This article analyzes the role of polymorphism T-511C genes of IL-1β cytokine for identification of genetic determinants of an increased risk for developing the chronic heart failure (CHF) in patients with arterial hypertension (AH) and metabolic syndrome (MS).
Materials and Methods: 246 people with CHF signs were examined. All the patients were diagnosed on anamnestic data and clinical signs. The patients were divided into two groups: cases with AH with MS (180 people) and cases with AH without MS (66 people). The age of patients was 57,2 ± 2,68. The control group consists of 60 relatively healthy people. As the genetic study material, the DNA samples were taken from lymphocytes of peripheral venous blood. The study of polymorphic loci was conducted using polymerase chain reaction (PCR) with the subsequent electrophoretic detection.
Results: It was found that S-allele and genotype C/C of polymorphic loci of T-511C gene IL-1β are associated with the inchasing risk of development, severity of clinical aspects and unfavorable character of CHF course in patients with AH and MS.
Discussion and Conclusions: The obtained data can play a significant role in early detection of cardiovascular events, in particular AH-MS-CHF that has great importance for effective preventive measures of the risk of serious sequels and objective assessment of the prospects for treatment.

Keywords: gene polymorphism, hypertension, congestive heart failure, metabolic syndrome, cytokines

For citation: Shamonina T. N., Radaeva O. A., Novikova L. V. The role of T-511C polymorphism in the IL-1β gene in patients with arterial hypertension and metabolic syndrome and its association with the risk of developing chronic heart failure. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2017; 27(3):345–354. DOI: 10.15507/0236-2910.027.201703.345-354

Contribution of co-authors: Т. Shamonina reviewed relevant medical literature, analyzed data and wrote the draft; О. Radaeva managed the research project, developed the concept and methods of research, reviewed relevant medical literature, analyzed data and revised the final article; L. Novikova managed the research project, critically reviewed the draft and edited the final article.

This work is licensed under a Creative Commons Attribution 4.0 License.