03. Ulanova TV, Inchina VI, Ruseykin NS, Khudoykina SV, Romanova EV. Investigation of the effect of new derivatives of 3-hydroxypyridine and reference drugs on the survival and some biochemical parameters of blood of white rats with experimental diabetes.

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UDK 615.27:612.12:599.323.45

DOI: 10.15507/0236-2910.026.201602.180-191

INVESTIGATION OF THE EFFECT OF NEW DERIVATIVES OF 3-HYDROXYPYRIDINE AND REFERENCE DRUGS ON THE SURVIVAL AND SOME BIOCHEMICAL PARAMETERS OF BLOOD OF WHITE RATS WITH EXPERIMENTAL DIABETES

Tatyana V. Ulanova (associated professor of Normal and Pathological Physiology Chair with course Hygiene, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Ph.D. (Medicine), ORCID: orcid.org/0000-0002-1371-4358, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Vera I. Inchina (Head of Pharmacology and Clinical Pharmacology Chair with course Pharmaceutical Technology, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Dr.Sci. (Medicine), ORCID: orcid.org/0000-0002-7840-6225, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Nikolay S. Ruseykin (Head of Normal and Pathological Physiology Chair with course Hygiene, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Ph.D. (Medicine), professor, ORCID: orcid.org/0000-0003-4429-295X, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Svetlana V. Khudoykina (doctoral student of Pharmacology and Clinical Pharmacology Chair with course Pharmaceutical Technology, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), ORCID: orcid.org/0000-0002-0436-2055, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Ella V. Romanova (associated professor of Biological and Pharmaceutical Chemistry Chair with course organization and management of Pharmacy, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Ph.D. (Chemistry) ORCID: orcid.org/0000-0002- 0330-3838, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Introduction. Due to the high risk of serious complications leading to early disability and premature death, and the high cost of treatment and rehabilitation of patients with diabetes in the near future may become a major health and social problem worldwide mortality of diabetic patients is several times higher mortality rate in the total cost of drug supply a patient with diabetes of the first type is an average of $ 715, and the second type – about $ 200 a year. Treatment of patients with severe complications, taking into account drug supply and cost of outpatient and inpatient care costs of 1,500 thousands dollars per year. Currently used drugs do not solve the problem, so a search of new drug compounds is relevant.
Materials and Methods. The possibility of the treatment of diabetes and its complications such as metabolic drugs in an experimental model of alloxan diabetes with exogenous hypercholesterolemia. Test compounds fumarate 3-hydroxypyridine and 3-hydroxypyridine nicotinate were synthesized at the Organic Chemistry Chair Mordovia State University by associate professor Semenov A.V.
Results. The study was revealed hypoglycemic and lipid-lowering activity of fumarate of 3-hydroxypyridine and nicotinate 3-hydroxypyridine.
Discussion and Conclusions. Our data indicate a further study of new promising compounds from the group of 3-hydroxypyridine as correctors metabolic disorders diabetes.

Keywords: diabet, fumarate, nicotinate, metabolic activity, hypercholesterolemia

For citation: Ulanova TV, Inchina VI, Ruseykin NS, Khudoykina SV, Romanova EV. Investigation of the effect of new derivatives of 3-hydroxypyridine and reference drugs on the survival and some biochemical parameters of blood of white rats with experimental diabetes. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2016; 2(26):180-191. DOI: 10.15507/0236-2910.026.201602.180-191

This work is licensed under a Creative Commons Attribution 4.0 License.