02. Balykova LA, Garina SV, Nazarova IS, Burenina LV. Evaluating the effectiveness of Elkar (L-carnitine) in premature infants.

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UDK 615.356:616-053.32

DOI: 10.15507/0236-2910.026.201602.168-179

EVALUATING THE EFFECTIVENESS OF ELKAR (L-CARNITINE) IN PREMATURE INFANTS

Larisa A. Balykova (director of Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Dr.Sci. (Medicine), professor, ORCID: orcid.org/0000- 0002-2290-0013, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Svetlana V. Garina (associated professor of Chair of Pediatrics, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Ph.D. (Medicine), ORCID: orcid.org/0000-0003-0673-7778, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Irina S. Nazarova (postgraduate student, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), ORCID: orcid.org/0000-0003-0090-6948, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Liana V. Burenina (senior lecturer of Chair of Pediatrics, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Ph.D. (Medicine), ORCID: orcid.org/ 0000-0001-8901-393X, This email address is being protected from spambots. You need JavaScript enabled to view it.)

Introduction. Recently in Russia there is a tendency to increase the proportion of premature infants, prolonged postnatal adaptation which may be associated with carnitine deficiency Early diagnosis and correction of carnitine deficiency in premature infants is possible to reserve the prevention of pathological conditions of the prenatal period in these patients.
Materials and Methods. 98 newborn infants have been examined with the help of clinical laboratory methods.
Results. It has been stated that the overwhelming majority of newborn infants irrespective of their gestational age and body mass at the moment of birth had reference ranges of crude carnitine and higher degree of floating carnitine in their peripheral blood within the first days of their lives. These changes are particularly characteristic for small pre-mature infants. Statistically significant differences between the levels of crude carnitine and floating carnitine depended on the gender of newborn infants have been revealed. Directly correlated dependence of the level of crude carnitine on the body mass at the moment of birth of small premature infants has been stated.
Discussion and Conclusions. It has been proved that implementing L-carnitine into the development care plan for premature infants facilitates quick body weight gain, significantly cuts down the period of tube feeding, lowers frequency of anemia development of premature infants and duration of neonatal jaundice. The ability of Elkar to correct functional diseases of cardio vascular system of premature infants has been shown.

Keywords: premature infants, L-carnitine, syndrome of cardio vascular deconditioning, carnitine inefficiency, Elkar

For citation: Balykova LA, Garina SV, Nazarova IS, Burenina LV. Evaluating the effectiveness of Elkar (L-carnitine) in premature infants. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2016; 2(26):168-179. DOI: 10.15507/0236-2910.026.201602.168-179

This work is licensed under a Creative Commons Attribution 4.0 License.