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doi: 10.15507/0236-2910.026.201601.134-143
THE ANALYSIS OF METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM IN THE PATIENTS WITH ARTERIAL HYPERTENSION IN THE REPUBLIC OF MORDOVIA
Lyudmila Goncharova (professor of Faculty Therapy chair with a course of Physiotherapy, Medical Institute, Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Dr.Sci. (Medicine), ORCID: http://orcid.org/0000-0002-4324-9071, This email address is being protected from spambots. You need JavaScript enabled to view it.)
Tatyana Degayeva (postgraduate student of Faculty Therapy chair with a course of Physiotherapy, Medical Institute, Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), ORCID: http://orcid.org/0000-0001-6922-5871, This email address is being protected from spambots. You need JavaScript enabled to view it.)
Natalya Sergutova (assistant of Faculty Therapy chair with a course of Physiotherapy, Medical Institute, Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Ph.D. (Medicine), ORCID: http://orcid.org/0000-0001-8274-7906, This email address is being protected from spambots. You need JavaScript enabled to view it.)
Hypertension (HTN or HT) is the main risk factor for cerebrovascular accidents and myocardial infarction, since it leads to imbalances during the vascular and thrombocytic part of hemostasis. In most cases, HTN is genetic in nature. Mutation of methylenetetrahydrofolate (MTHFR) gene in positions C677T and A1298C is supposedly one of the major factors in evolvement of this medical condition. High percentage of patients with complicated hypertension persists in Republic of Mordovia, so the article provides data analysis of polymorphism of MTHFR gene in patients with primary hypertension of Mordvinian and Russian ethnicity residing in the Republic.
Materials and Methods The study involved 113 patients (50,4 % – Mordvinian and 49,6 % – Russian nationalities) with hypertension (stages II-III in classification of Society of cardiology of Russian Federation, year 2008, BP <140/90 mm Hg). Along with the traditional clinical and instrumental studies, the authors conducted identification of alleles of polymorphic markers by polymerase chain reaction method. Statistical analysis was performed with implementation of software packages “Statistica for Windows 6.0” (StatSoft), “SPSS” (version 14.0), “MS Excel XP” (Microsoft). The authors used χ2 in the process of consideration of the frequencies of genotypes and alleles in individual groups of patients.
Results Analysis of the distribution of genotypes of the MTHFR gene at position 677 and positions A1298C revealed the predominance of intermediate genotypes CT and AC in male and female patients with hypertension, with no correlation to nationality. Adverse CT genotype of MTHFR gene at position 677 is found in 20 % of patients with hypertension among Mordvinian males and 2,5 % – among hypertensive Russian females. Pathological CC genotype of MTHFR gene in the A1298C position was identified either in Mordvinian (from 2,3 % to 27 %) and Russian (from 19,3 % to 33,7 %) patients.
Discussion and Conclusions Revealed combinations of intermediate and pathological genotypes of this gene enable the authors to suggest an increased liability for the development of thrombosis in this group of patients with HT.
Keywords: hypertension, hemostasis system, methylenetetrahydrofolate reductase gene polymorphism at positions C677T and A1298C, titular population
For citation: Goncharova LN, Degayeva TA, Sergutova NP. The analysis of methylenetetrahydrofolate reductase gene polymorphism in the patients with arterial hypertension the Republic of Mordovia. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2016; 1(26):134-143. doi: 10.15507/0236-2910.026.201601.134-143
This work is licensed under a Creative Commons Attribution 4.0 License.
