04. Balykova LA, Ivyanskiy SA, Gromova YeV, Varlashina KA, Shchekina NV, Davydov PA. Pathogenesis aspects of formation of the disadaptation changes of cardiovascular system, coursed by intensive physical activities.

UDC 611.1:615.825.5

DOI: 10.15507/0236-2910.026.201603.336-348

PATHOGENESIS ASPECTS OF FORMATION OF THE DISADAPTATION CHANGES OF CARDIOVASCULAR SYSTEM, COURSED BY INTENSIVE PHYSICAL ACTIVITIES

Larisa A. Balykova
head of Chair of Pediatrics, director of Medical Institute, National Research Mordovia State University (68, Bolshevistskaya St, Saransk, Russia), Dr.Sci. (Medicine), professor, ORCID: http://orcid.org/0000-0002-2290-0013, This email address is being protected from spambots. You need JavaScript enabled to view it.

Stanislav A. Ivyanskiy
docent of Chair of Pediatrics, Medical Institute, National Research Mordovia State University (68, Bolshevistskaya St, Saransk, Russia), Ph.D. (Medicine), ORCID: http://orcid.org/0000-0003-0087-4421, This email address is being protected from spambots. You need JavaScript enabled to view it.

Yelena V. Gromova
deputy director of Medical Institute, professor of the Normal and Pathological Physiology with the Hygiene course chair, National Research Mordovia State University (68, Bolshevistskaya St, Saransk, Russia), Dr.Sci. (Biology), ORCID: http://orcid.org/0000-0001-9255-2571, This email address is being protected from spambots. You need JavaScript enabled to view it.

Kristina A. Varlashina
assistant of Chair of Pediatrics, Medical Institute, National Research Mordovia State University (68, Bolshevistskaya St, Saransk, Russia), ORCID: http://orcid.org/0000-0003-4918-8596, This email address is being protected from spambots. You need JavaScript enabled to view it.

Natalya V. Shchekina
head of the Division of Cardiology, Republican Children’s Clinical Hospital (15, Rozy Lyuksemburg St., Saransk, Russia), ORCID: http://orcid.org/0000-0001-6207-5196, This email address is being protected from spambots. You need JavaScript enabled to view it.

Pavel A. Davydov
student of Medical Institute, National Research Mordovia State University (68, Bolshevistskaya St, Saransk, Russia), ORCID: http://orcid.org/0000-0001-5441-408X, This email address is being protected from spambots. You need JavaScript enabled to view it.

Introduction: Over recent years one of the topical issues in Russia is the assessment of cardiovascular system of the people with intense physical activity. The complexity of this issue is caused by the challenges in understanding of how pathological changes in heart may lead to sudden cardiac death.
Materials and Methods: The research consists of experimental and clinical assessments. In the experimental part of assessment mice were exposed to rigorous exercise. In the clinical part 142 adolescents engaged in regular sports activities were examined using such methods as lab test and special exam.
Results: It has been established that rigorous exercise of laboratory animals leads to the development of ultrastructural myocardial injuries and adrenaline burst. Abovementioned changes correlate to survival rate of the animals. Clinical observations revealed that regular exercises stimulated the development of myocardial hypertrophy, vegetative disturbances, and changes in biochemical values.
Discussion and Conclusions: It was shown that besides myocardial hypertrophy and hemodynamic disorders there are also other pathophysiological mechanisms that cause the development of maladaptation abnormalities in cardiovascular system.

Keywords: heart, physical activity, stress, disadaptation, cardiovascular system

For citation: Balykova LA, Ivyanskiy SA, Gromova YeV, Varlashina KA, Shchekina NV, Davydov PA. Pathogenesis aspects of formation of the disadaptation changes of cardiovascular system, coursed by intensive physical activities. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2016; 3(26):336-348. DOI: 10.15507/0236-2910.026.201603.336-348

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