Engineering Technologies and Systems - 07. Balykova L. A., Samoshkina Ye. S., Ivyanskiy S. A., Akashkina Ye. Yu., Maksimova Ye. Yu., Cheknaykina N. V., Motorkina A. S. Amiodarone-induced secondary thyroid dysfunctions in children

UDC 616.441-053.2

DOI: 10.15507/0236-2910.027.201703.382-396

Amiodarone-induced secondary thyroid dysfunctions in children

Larisa A. Balykova
Director of the Medical Institute, Head of Chair of National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Dr.Sci. (Medicine), Professor, Corresponding Member of RAS, ORCID: http://orcid.org/0000-0002-2290-0013,This email address is being protected from spambots. You need JavaScript enabled to view it.

Elena S. Samoshkina
Associate Professor of Chair of Pediatrics, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Ph.D. (Medicine), ORCID: http://orcid.org/0000-0002-8192-7902, This email address is being protected from spambots. You need JavaScript enabled to view it.

Stanislav A. Ivyanskiy
Associate Professor of Chair of Pediatrics, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), Ph.D. (Medicine), ORCID: http://orcid.org/0000-0003-0087-4421, This email address is being protected from spambots. You need JavaScript enabled to view it.

Yekaterina Yu. Akashkina
Assistant of Chair of Pediatrics, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), ORCID: http://orcid.org/0000-0002-5365-5655, This email address is being protected from spambots. You need JavaScript enabled to view it.

Yelena Yu. Maksimova
Clinical Resident, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), ORCID: http://orcid.org/ 0000-0002-6486-1921, This email address is being protected from spambots. You need JavaScript enabled to view it.

Natalya V. Cheknaykina
Clinical Resident, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), ORCID: http://orcid.org/0000-0001-5819-3763, This email address is being protected from spambots. You need JavaScript enabled to view it.

Anna S. Motorkina
Student, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya St., Saransk 430005, Russia), ORCID: http://orcid.org/0000-0001-5882-3884, This email address is being protected from spambots. You need JavaScript enabled to view it.

Introduction: The choice of effective and safe antiarrhytmic therapy for children and adolescents is relevant issue for public health. The difficulty in choising therpeutic tactics is caused by the variety of formation of arrhythmias and the side effects of drugs.
Materials and Methods: The condition of thyroid system in 45 children (20 girls, 25 boys) suffering from disturbances of a rhythm within a year after the end of treatment by Amiodaronum is analyzed. The average age of the surveyed patients was 8,26 ± 0,9 years. A comprehensive examination including an assessment of a hormonal profile (a thyroxin (T4), triodothyronine (T3), thyrotrophic hormone (TTG), antibodies to a thyroid peroxidase and a thyreoglobulin (AT to TPO and TG)), ultrasound examination (US) of a thyroid gland, a standard electrocardiography at rest (ECG) and the Holter monitoring (HM) before, in 3, 6 and 12 months of therapy was conducted.
Results: It has been established that prescription of Amiodarone was followed by changes in the level the thyroid’s hormones, but in most cases within normal values. Thyroidopathya (subclinical are more often) were diagnosed for three patients. In 4.4 % of cases the hypothyroid and in 2.2 % of cases the thyrotoxicosis were detected.
Discussion and Conclusions: It was shown that reception of medicine resulted in changes the sizes of a thyroid gland, but rarely followed by violations of functions.

Keywords: amiodarone, hypothyrosis, thyrotoxicosis, children, thyroid dysfunction

For citation: Balykova L. A., Samoshkina Ye. S., Ivyanskiy S. A., Akashkina Ye. Yu., Maksimova Ye. Yu., Cheknaykina N. V., Motorkina A. S. Amiodarone-induced secondary thyroid dysfunctions in children. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2017; 27(3):382–396. DOI: 10.15507/0236-2910.027.201703.382-396

Contribution of the co-authors: L. A. Balykova: concept development, scientific supervision, critical analysis and revision of the final text; E. S. Samoshkina: formalized data analysis, writing the daft, revision of the final text, reviewing the relevant literature, analysis of the clinical part of the work; S. A. Ivyansky: reviewing the relevant literature, formatting the final text of the article, editing; Ye. Yu. Akashkina, Ye. Yu. Maksimova, N. V. Cheknaykina, A. S. Motorkina: reviewing the relevant literature, formatting the final text of the article.

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