01. Lubskaya N. S., Nikonorova M. A., Granitov V. M., Matros O. I. Variants of thyroid dysfunction in patients with chronic hepatitis C from residents of the Altai region

UDC 616.441:616.36-002(571.150)

DOI: 10.15507/0236-2910.027.201703.304-314

Variants of thyroid dysfunction in patients with chronic hepatitis C from residents of the Altai region

Nina S. Lubskaya
Infectious Disease Doctor, City Polyclinic no. 3 of Barnaul (35 Molodezhnaya St., Barnaul 656031, Russia), ORCID: http://orcid.org/0000-0001-7256-4532, This email address is being protected from spambots. You need JavaScript enabled to view it.

Marina A. Nikonorova
Professor of the Chair of Infectious Diseases and Phthisiology, Altai State Medical University (40 Prospekt Lenina, Barnaul 656038, Russia), Dr.Sci. (Medicine), ORCID: http://orcid.org/0000-0001-6621-9310, This email address is being protected from spambots. You need JavaScript enabled to view it.

Vladimir M. Granitov
Professor of the Chair of Infectious Diseases and Phthisiology, Altai State Medical University (40 Prospekt Lenina, Barnaul 656038, Russia), Ph.D. (Medicine), professor, ORCID: http://orcid.org/0000-0002-9916-7446, This email address is being protected from spambots. You need JavaScript enabled to view it.

Olga I. Matros
Associate of the Chair of Infectious Diseases and Phthisiology, Altai State Medical University (40 Prospekt Lenina, Barnaul 656038, Russia), Ph.D. (Medicine), ORCID: http://orcid.org/0000-0003-2928-2737, This email address is being protected from spambots. You need JavaScript enabled to view it.

Introduction: HCV is the cause of not only cirrhosis, hepatocellular carcinoma, but also of extrahepatic manifestations. Currently, HCV is considered as an independent risk factor for thyroid pathology. In recent years, the level of pathology of the thyroid gland in the Altai region has increased 16.4 times. It determined the study of the features of the thyroid status in patients with chronic hepatitis C (CHC) in the Altai region.
Materials and Methods: A prospective, dynamic, clinical, laboratory and instrumental examination of 240 patients with CHC (47.5 % of men and 52.5 % of women aged 18 to 50 years) was carried out, 120 of them had HCV (49.1 % of men and 50, 9 % of women, aged 18 to 50 years, mean age 41.1 ± 9.91 years) who did not receive antiviral therapy (HTV), the pathology of the thyroid gland was identified for the first time the pathology of the thyroid gland. The study included the definition of TSH, general and free T3, T4, antibodies to thyreperoxidase (APPO), ultrasound examination of the thyroid gland. The diagnosis of CHC is based on: HCV RNA, anti-HCV (core, NS3-5), blood biochemistry, fibrosis level by Metavir (elastometry, PBP).
Results: Discussion and Conclusions: The patients with CHC have euthyroidism and hypothyroidism more often. The relationship of TD with the duration of HCV infection can be regarded as its extrahepatic manifestations, and not as comorbid conditions. Thorough examination of the thyroid status makes it possible to identify people with TD. It can be reflected in the choice of PVT and will determine the prognosis of the development of side effects.
Discussion and Conclusions: The patients with CHC have euthyroidism and hypothyroidism more often. The relationship of TD with the duration of HCV infection can be regarded as its extrahepatic manifestations, and not as comorbid conditions. Thorough examination of the thyroid status makes it possible to identify people with TD. It can be reflected in the choice of PVT and will determine the prognosis of the development of side effects.

Keywords: chronic hepatitis C, extrahepatic manifestations, thyroid gland, hypothyroidism, euthyroidism, autoimmune thyroiditis

For citation: Lubskaya N. S., Nikonorova M. A., Granitov V. M., Matros O. I. Variants of thyroid dysfunction in patients with chronic hepatitis C from residents of the Altai region. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2017; 27(3):304–314. DOI: 10.15507/0236-2910.027.201703.304-314

Contribution of the co-authors: N. S. Lubskaya: carrying out of instrumental-diagnostic part of the research; writing and revision of the draft; data processing on the PC; M. A. Nikonorova: development of the conceptual framework, scientific guidance, critical analysis and revision of the draft; V. M. Granitov: consulting on the clinical part of the work, formalized data analysis, reviewing the scientific literature; O. I. Matros: formalized data analysis, reviewing the scientific literature.

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