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DOI: 10.15507/0236-2910.026.201602.160-167
HERPETIC KERATITIS OUTCOMES DEPENDING ON IMMUNE STATUS OF PATIENTS
Svetlana V. Aksenova (professor of Hospital Surgery Chair with courses of Traumatology and Orthopedics, Ophthalmology and Dentistry, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), Dr.Sci. (Medicine), ORCID: orcid.org/0000-0002-0186-5044, This email address is being protected from spambots. You need JavaScript enabled to view it.)
Marina V. Malkina (doctoral student of Hospital Surgery Chair with courses of Traumatology and Orthopedics, Ophthalmology and Dentistry, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), ORCID: orcid.org/0000-0002-2387-7097, This email address is being protected from spambots. You need JavaScript enabled to view it.)
Anastasiya V. Sedoykina (doctoral student of Hospital Surgery Chair with courses of Traumatology and Orthopedics, Ophthalmology and Dentistry, Medical Institute, National Research Ogarev Mordovia State University (68, Bolshevistskaya St., Saransk, Russia), ORCID: orcid.org/0000-0001-9969-2075, This email address is being protected from spambots. You need JavaScript enabled to view it.)
Introduction. Herpetic keratitis with the formation frequency of several million patients a year occupy an important place in infectious pathology of the eye and remain one of actual problems of ophthalmology. The lack of reliable ways of dealing with ophthalmic herpes dictates the necessity of finding optimal ways to treat patients, what prompted us to conduct this research. Purpose of the study. To evaluate the effect of the standard treatment regimen herpetic keratitis on the parameters of the immune status of the patient.
Materials and Methods. We examined and treated 15 patients (15 eyes) with herpetic keratouveitis. The control group consisted of 20 healthy people of similar age (20 eyes). Comparative evaluation of clinical and immunological status of patients conducted before and after standard therapy.
Results. In the study of these immunological parameters of examinees were detected increase in the number leucocytes, lymphocytes, neutrophils absorbency, HCT-activity of neutrophils, the CIC in patients with herpetic keratitis during exacerbation of the disease, however, a decrease amount of TFR and TFS cells with helper and suppressor activity. During treat-ment immunological parameters have normalized somewhat, but were higher than the reference value.
Discussion and Conclusions. The research showed that the base therapy does not provide normalization of cellular immune status even when clinical recovery, with the result that retained the ability of cells to maintain local inflammatory focus, complicate the regeneration process, promote chronicity and recurrence of the herpetic keratitis. These facts make it necessary to change the program of treatment of patients with this pathology and introduce the recommended range of products such as antioxidant and immunomodulatory activities.
Keywords: ophthalmoherpes, keratouveit, herpes simplex herpes, local immunity, cellular immunity, corneal opacity, basic therapy
For citation: Aksenova SV, Malkina MV, Sedoykina AV. Herpetic keratitis outcomes depending on immune status of patients. Vestnik Mordovskogo universiteta = Mordovia University Bulletin. 2016; 2(26):160-167. DOI: 10.15507/0236-2910.026.201602.160-167
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